Andrew was born at Damascus, about the year 660, and embraced the monastic life at Jerusalem, from which city he sometimes takes his name. Hence he was sent on ecclesiastical business to Constantinople, where he became a Deacon of the Great Church, and Warden of the Orphanage. His first entrance on public life does no credit to his sanctity. During the reign of Philippicus Bardanes, (711-714) he was raised by that usurper to the Archiepiscopate of Crete; and shortly afterwards was one of the Pseudo-Synod of Constantinople, held under the Emperor's auspices in A.D.712, which condemned the Sixth Oecumenical Council, and restored the Monothelite heresy. At a later period, however, he returned to the faith of the Church, and refuted the error into which he had fallen. Seventeen of his Homilies, rather laboured than eloquent, remain to us: that in which he rises highest is, not unnaturally, his sermon on S. Titus, Apostle of Crete. He died in the island of Hierissus, near Mitylene, about the year 732.

As a poet, his most ambitious composition is the Great Canon; which, partially used during other days of Lent, is sung right through on the Thursday of Mid-Lent week, called, indeed, from that hymn. His Triodia in Holy Week, and Canon on Mid-Pentecost, are fine; and he has a great variety of spirited Idiomela scattered through the Triodion and Pentecostarion.