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It is an appeal to universal reason, to the consciences of sinners themselves; it is a challenge to all their power and policy, to all their interest and alliances, whether they, or any of them, can find out, or can force out, a way of escape from the vindictive justice and wrath of God. It intimates that the neglecters of this great salvation will be left not only without power, but without plea and excuse at the judgment day.

(M. Henry.)

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KJV: How shall we escape, if we neglect so great salvation; which at the first began to be spoken by the Lord, and was confirmed unto us by them that heard him;

WEB: how will we escape if we neglect so great a salvation—which at the first having been spoken through the Lord, was confirmed to us by those who heard;