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1. The great reigning sin.

2. The great ruining sin.

3. That which is at the bottom of all sin.

(J. P. Lange.)

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KJV: Take heed, brethren, lest there be in any of you an evil heart of unbelief, in departing from the living God.

WEB: Beware, brothers, lest perhaps there be in any one of you an evil heart of unbelief, in falling away from the living God;