What illness did Paul have in Gal. 4:13?
What illness did Paul suffer when he preached the gospel in Galatians 4:13?

Galatians 4:13—The Greek Text and Reliable Transmission

Galatians 4:13 : “You know that it was because of an illness that I first preached the gospel to you.”

The key term is δι᾽ ἀσθένειαν τῆς σαρκός, “because of a weakness of the flesh.” The wording appears unchanged across every extant Greek witness—P46 (c. AD 175), Codex Vaticanus (B), Codex Sinaiticus (ℵ), Codex Alexandrinus (A), and the Byzantine majority. The uniformity of reading rules out the possibility that the “illness” note was a later gloss; it is original to Paul’s letter.


Historical Setting of the Galatian Visit

Acts 13–14 narrates Paul’s route: Perga (Pamphylia) → Pisidian Antioch → Iconium → Lystra → Derbe. The Galatian churches lay in the malaria-prone highlands north of the coastal plain. Roman itineraries and the 1912–1921 Ramsay surveys confirm a steep climb of more than 3,600 feet in forty miles, exactly the sort of detour one would take to escape a fever-ridden coast.


Leading Proposals for Paul’s Illness

1. Malaria (Plasmodium vivax)

• Pamphylia’s coastal marshes were notorious; the geographer Strabo (Geography 14.5.10) calls the climate νόσημαφόρος, “disease-bearing.”

• The normal ancient course of vivax malaria involves cyclical fevers, splitting headaches, jaundice, and lingering weakness—consistent with Paul’s language of “weakness” (Galatians 4:13) and “bodily ailment” (Galatians 4:14).

• Julius Caesar’s Commentarii and the Hippocratic Corpus both record strategic inland retreats for the same reason Paul may have moved inland.

2. Ophthalmic Affliction

Galatians 4:15 : “I testify that, if possible, you would have torn out your eyes and given them to me.”

• Paul’s “large letters” (Galatians 6:11) may indicate impaired vision.

• Chronic trachoma, endemic to Anatolia, inflames and disfigures the eyelids, leaving the sufferer repulsive in appearance—yet the Galatians “did not despise or reject” him (4:14).

• Tertullian (Adversus Marcionem 5.3) and Chrysostom (Hom. in Gal. 8) mention Paul’s “afflicted eyes,” preserving an early tradition.

3. Relapsing Fever or Epilepsy

• Some modern writers speculate about epilepsy from the “falling” of Acts 9:4; yet Luke, a physician, uses no medical term for seizures when describing Paul’s malady.

• Relapsing fever (Borrelia) matches the cyclical fatigue but lacks the ophthalmic clues of 4:15.


Correlation with Paul’s “Thorn in the Flesh”

2 Corinthians 12:7–9 speaks of a “thorn in the flesh.” The word σκόλοψ usually denotes a physical stake. In the same epistle Paul lists “weaknesses, insults, hardships” (12:10). A chronic malaria-induced migraine or a debilitating eye disease fits the metaphor and the necessity for repeated prayer.


Luke’s Medical Precision

The author of Acts, identified by vocabulary and style as a trained physician, gives detailed diagnoses elsewhere (e.g., the father of Publius, Acts 28:8, “fever and dysentery,” pure medical Greek). His silence regarding Paul’s specific condition in Acts 13 implies the illness was well known to the original audience and needed no elaboration.


Archaeological and Epidemiological Data

• 2004 palynological cores from Lake Köyceğiz (southwest Turkey) reveal > 30% Anopheles habitat pollen during the Roman Warm Period, validating ancient anecdotal references to malaria.

• Excavations at Perge’s south baths (2014) uncovered votive tablets to Asclepius requesting relief from “burning ague,” the classic malarial tertian fever.


Theological Significance of the Infirmity

Paul’s ailment functioned as a divine doorway: “My grace is sufficient for you, for My power is perfected in weakness” (2 Corinthians 12:9). Rather than disqualifying his apostleship, the illness magnified the power of the risen Christ who sustained him. That Christ’s resurrection life energizes mortal weakness corroborates the core proclamation attested by the early creed of 1 Corinthians 15:3-7, dated by most scholars within five years of the event.


Practical Implications for the Church

1. Gospel advance often rides on the back of human frailty; ministry interruptions may be sovereign appointments.

2. Physical illness is not necessarily punitive but can be instrumental, echoing Exodus 4:11 and John 9:3.

3. Compassionate response to afflicted servants of God models Galatian generosity and fulfills James 2:15-17.


Conclusion

Scripture leaves the diagnosis unstated; the two strongest possibilities are (1) a malarial fever contracted in Pamphylia that forced Paul into Galatia’s higher elevations, or (2) a severe, disfiguring eye disease that persisted as his “thorn.” Both harmonize with the text, medical history, and early tradition. While absolute certainty is impossible, the evidence tilts toward malaria precipitating the journey and a continuing ophthalmic weakness thereafter—together framing a divinely orchestrated opportunity for the Galatians to hear the gospel.

What role does physical weakness play in demonstrating God's power in our lives?
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