The House of Simon is a significant location mentioned in the New Testament, associated with two different individuals named Simon. These accounts provide insight into the life and ministry of Jesus Christ, as well as the early Christian community.

1. Simon the Leper: The House of Simon the Leper is mentioned in the Gospels as the setting for a notable event in the life of Jesus. In Matthew 26:6-7 , it is recorded, "While Jesus was in Bethany in the home of Simon the leper, a woman came to Him with an alabaster jar of very expensive perfume, which she poured on His head as He was reclining at the table." This act of anointing by the woman, identified in other Gospels as Mary of Bethany, is a profound moment of devotion and foreshadows Jesus' impending death and burial. The presence of Jesus in the house of a leper underscores His mission to reach out to the marginalized and those considered unclean by societal standards.

2. Simon the Tanner: Another significant mention of a house belonging to a Simon is found in the Acts of the Apostles. In Acts 10:6 , it is noted that Simon Peter stayed at the house of Simon the Tanner in Joppa: "He is staying with Simon the tanner, whose house is by the sea." This location becomes pivotal in the narrative of Peter's vision and the subsequent inclusion of Gentiles into the early Christian Church. The occupation of Simon as a tanner, which involved working with animal hides, would have been considered ritually unclean by Jewish standards, yet Peter's stay there signifies the breaking down of traditional barriers and the expansion of the Gospel to all peoples.

Both accounts of the House of Simon highlight key themes in the New Testament: the inclusivity of Jesus' ministry, the breaking of social and ritual boundaries, and the preparation for the spread of the Gospel beyond Jewish communities. These homes serve as backdrops for transformative events that illustrate the radical nature of Jesus' message and the early Church's mission.