1044. gaggraina
Lexical Summary
gaggraina: Gangrene

Original Word: γάγγραινα
Part of Speech: Noun, Feminine
Transliteration: gaggraina
Pronunciation: GANG-grain-ah
Phonetic Spelling: (gang'-grahee-nah)
KJV: canker
NASB: gangrene
Word Origin: [from graino "to gnaw"]

1. an ulcer, ("gangrene")

Strong's Exhaustive Concordance
canker.

From graino (to gnaw); an ulcer ("gangrene") -- canker.

NAS Exhaustive Concordance
Word Origin
perhaps from graó (to gnaw)
Definition
a gangrene, an eating sore
NASB Translation
gangrene (1).

Thayer's Greek Lexicon
STRONGS NT 1044: γάγγραινα

γάγγραινα, γαγγραινης, (γράω or γραίνω to gnaw, eat), a gangrene, a disease by which any part of the body suffering from inflammation becomes so corrupted that, unless a remedy be seasonably applied, the evil continually spreads, attacks other parts, and at last eats away the bones: 2 Timothy 2:17 (where cf. Ellicott). (Medical writings (cf. Wetstein (1752) at the passage cited); Plutarch, diser. am. et adulat. c. 36.)

Topical Lexicon
Physical Background

In Greco-Roman medicine the term γάγγραινα described a necrotic sore that silently devoured healthy tissue until amputation or death resulted. Physicians such as Hippocrates and Galen warned of its stealth, rapid spread, foul odor, and deadly outcome. First-century readers therefore heard in the word an image of relentless corruption jeopardizing the whole body.

Biblical Occurrence

Paul employs the term once—“their talk will spread like gangrene” (2 Timothy 2:17)—to depict the effect of false teaching within the church at Ephesus. The single use does not diminish its weight; rather, the rarity sharpens its edge. Paul chooses the most graphic medical term in his vocabulary to alert Timothy to the urgency of decisive pastoral action.

Metaphorical Force in Pauline Teaching

1. Progressive contagion: As gangrene advances cell by cell, so “irreverent, empty chatter” (2 Timothy 2:16) infiltrates hearts and households.
2. Destruction of life: Physical gangrene, if untreated, kills the body; doctrinal error, if unchallenged, kills faith (compare 1 Timothy 1:19).
3. Necessity of radical removal: Ancient surgeons cut away necrotic flesh. Likewise, Timothy is to “reject foolish and ignorant controversies” (2 Timothy 2:23) and, when necessary, separate unrepentant teachers from fellowship (Titus 3:10–11).

Old Testament Resonances

Though γάγγραινα itself is absent from the Septuagint, its moral counterpart appears in images of:
• Leaven permeating dough (Exodus 12:15; compare 1 Corinthians 5:6).
• A “root that bears poisonous fruit” (Deuteronomy 29:18; Hebrews 12:15).

The consistent Scriptural message is that unchecked evil never remains static.

Historical and Cultural Context

Hymenaeus and Philetus (2 Timothy 2:17) spread the claim that “the resurrection has already taken place” (2 Timothy 2:18). In Greek thought a purely spiritualized afterlife was common; by adopting such ideas these men undermined bodily resurrection, the gospel’s eschatological hope (1 Corinthians 15:12-19). Paul’s medical metaphor thus confronts a syncretism that threatened apostolic doctrine during the closing years of his ministry.

Pastoral Implications

• Vigilance: Leaders must diagnose doctrinal infection early (Acts 20:28-30).
• Biblical precision: “Rightly handling the word of truth” (2 Timothy 2:15) is the prescribed antidote.
• Redemptive discipline: The goal is healing, not humiliation—“restore him gently” (Galatians 6:1).
• Community responsibility: Congregations are to “test the spirits” (1 John 4:1) and refuse to “itch for what is new” (2 Timothy 4:3-4).

Theological Significance

1. Holiness of doctrine: Truth is not a negotiable preference but a living trust (2 Timothy 1:13-14).
2. Corporate solidarity: Just as gangrene endangers the entire body, falsehood in one member imperils all (1 Corinthians 12:26).
3. Eschatological stakes: Distortion concerning the resurrection strikes at the heart of salvation history; if death is not finally conquered in the body, Christ’s own resurrection is emptied of power.

Application for Contemporary Ministry

• Catechesis that grounds believers in the whole counsel of God forestalls infection.
• Digital media can accelerate the spread of error; discerning gatekeepers are essential.
• Church discipline, lovingly applied, remains a biblical mandate, not a relic.
• Hope in the final, bodily resurrection fortifies congregations against spiritualizing trends that reduce Christianity to ethical platitudes.

Summary

Strong’s Greek 1044, γάγγραινα, serves as Scripture’s stark warning that error, like a lethal sore, must be confronted swiftly and surgically lest it ravage the Body of Christ.

Forms and Transliterations
γαγγραινα γάγγραινα gangraina gángraina
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Englishman's Concordance
2 Timothy 2:17 N-NFS
GRK: αὐτῶν ὡς γάγγραινα νομὴν ἕξει
NAS: like gangrene. Among them are Hymenaeus
KJV: will eat as doth a canker: of whom is
INT: of them as a gangrene pasture will have

Strong's Greek 1044
1 Occurrence


γάγγραινα — 1 Occ.

1043
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