5521. cholé
Lexical Summary
cholé: Gall, bile

Original Word: χολή
Part of Speech: Noun, Feminine
Transliteration: cholé
Pronunciation: kho-LAY
Phonetic Spelling: (khol-ay')
KJV: gall
NASB: gall
Word Origin: [feminine of an equivalent perhaps akin to the same as G5514 (Χλόη - Chloe's) (from the greenish hue)]

1. "gall" or bile
2. (by analogy) poison or an anodyne (wormwood, poppy, etc.)

Strong's Exhaustive Concordance
gall.

Feminine of an equivalent perhaps akin to the same as Chloe (from the greenish hue); "gall" or bile, i.e. (by analogy) poison or an anodyne (wormwood, poppy, etc.) -- gall.

NAS Exhaustive Concordance
Word Origin
a prim. word
Definition
gall (a bitter herb)
NASB Translation
gall (2).

Thayer's Greek Lexicon
STRONGS NT 5521: χολή

χολή, χολῆς, (equivalent to χόλος, from χέω to pour out (now thought to be connected with χλόη, χλωρός, etc. 'yellowish green'; cf. Curtius, § 200; Vanicek, p. 247)), first found in Archilochus (8th century B.C.), afterward in Aeschylus and following.

1. bile, gall: Matthew 27:34 (cf. the Sept. Psalm 68:22 ()) (cf. B. D., under the word Gall); Acts 8:23 (on which see πικρία); for מְרֵרָה, Job 16:13.

2. in the O. T. it is also used of other bitter things; for לַעֲנָה, wormwood, Proverbs 5:4; Lamentations 3:15; hence, some understand the word in Matthew 27:34 to mean myrrh, on account of Mark 15:23; but see σμυρνίζω, 2; (B. D. as above).

Topical Lexicon
Overview

χόλη denotes bile or gall, the intensely bitter bodily fluid that readily became a metaphor for moral and spiritual bitterness. In Scripture it appears only twice, yet each setting is strategic—one in the atoning suffering of Jesus Christ, the other in apostolic confrontation of sin.

Physical Substance and Symbolic Force

Ancient physicians identified gall as a corrosive liquid stored in the liver, useful in dyes and cures but feared for its acrid taste and toxic effect. Scripture adopts this natural bitterness to describe both the taste of suffering and the poison of sin. The metaphor rests on two observable realities: gall is repugnant to the tongue, and even a small amount can taint an entire mixture (compare Ecclesiastes 10:1).

Old Testament Background

The Hebrew poets repeatedly linked “gall” (rōʾsh) with wormwood and hemlock to portray cruelty or divine judgment (Deuteronomy 32:32-33; Jeremiah 8:14; Lamentations 3:5). Psalm 69:21 foretold, “They put gall in My food and gave Me vinegar to drink.” The Septuagint renders the Hebrew “poison” with χόλη, preparing the vocabulary later used in the passion narrative.

Matthew 27:34 — The Cup Refused

“There they offered Him wine to drink, mixed with gall; but after tasting it, He refused to drink it.” (Matthew 27:34)

Roman executioners customarily gave a stupefying draught to dull pain. By prophecy, the mixture offered to Jesus was adulterated with gall, recalling Psalm 69:21. His refusal underscores at least three truths:

1. Prophetic fulfillment—He identifies Himself with the righteous sufferer of the Psalm.
2. Conscious obedience—He drains the cup the Father has given without dulling His faculties (John 18:11).
3. Moral contrast—while His persecutors mix gall in mockery, He offers the cup of the new covenant free of bitterness (Matthew 26:27-28).

Acts 8:23 — The Poison of Bitterness

“For I see that you are poisoned by bitterness and captive to iniquity.” (Acts 8:23)

Peter confronts Simon the magician, exposing his mercenary request for apostolic power. χόλη here operates metaphorically: the hidden bile of the heart that corrodes faith and enslaves the will. The phrase “gall of bitterness” reflects Deuteronomy 29:18, “a root that bears gall and wormwood,” warning Israel against apostasy. Peter joins gall with “bond of iniquity,” showing that bitterness can both flow from sin and deepen its chains.

Theological Reflections

1. Substitution and Sympathy: The Messiah bears every bitter ingredient of the curse (Isaiah 53:4-5), yet chooses to taste human sorrow without anesthetic.
2. Sanctification: The Spirit exposes gall in the believer’s heart; repentance expels it before it defiles many (Hebrews 12:15).
3. Judgment: Persistent bitterness is evidence of unregenerate bondage, awaiting the bitter cup of wrath (Revelation 14:10).

Pastoral and Ministry Applications

• In counseling, Matthew 27:34 encourages sufferers that Christ knowingly shared the full bitterness of pain.
• Church discipline, patterned after Acts 8:23, addresses not merely wrong actions but the toxic motive beneath them.
• Preachers should warn that spiritual gifts cannot be purchased; the attempt betrays a heart still steeped in gall.

Historical Notes

Early Christian writers (e.g., Justin Martyr, Dialogue 97) cited Psalm 69:21 and Matthew 27:34 to demonstrate prophecy fulfilled in Jesus. Medical texts of Hippocrates and Dioscorides identified gall as both remedy and toxin, illustrating the double-edged power of bitterness later echoed by Augustine: “The same cross is perfume to the humble and gall to the proud” (Enarrationes in Psalmos 64).

Practical Exhortations

• Guard communion: replace every seed of resentment with the forgiving mind of Christ (Ephesians 4:31-32).
• Embrace trials without anesthetic shortcuts, trusting the Father who mixes no gall in the cup of salvation (James 1:2-4).
• Pray that the Spirit would turn any gall within us into zeal for holiness, lest bitterness spread through the body (Hebrews 12:15).

χόλη thus stands as both a literal ingredient in the crucible of redemption and a vivid image of the heart’s hidden poisons. Where Christ drains bitterness, believers find sweet freedom; where bitterness rules, only bondage remains.

Forms and Transliterations
χολή χολην χολήν χολὴν χολης χολής χολῆς χόλω χονδριτών cholen cholēn cholḕn choles cholês cholēs cholē̂s
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Englishman's Concordance
Matthew 27:34 N-GFS
GRK: οἶνον μετὰ χολῆς μεμιγμένον καὶ
NAS: mixed with gall; and after tasting
KJV: with gall: and
INT: wine with gall mingled and

Acts 8:23 N-AFS
GRK: εἰς γὰρ χολὴν πικρίας καὶ
NAS: For I see that you are in the gall of bitterness
KJV: art in the gall of bitterness, and
INT: in indeed a gall of bitterness and

Strong's Greek 5521
2 Occurrences


χολὴν — 1 Occ.
χολῆς — 1 Occ.

5520
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