The phrase "God's hand against him" is a biblical expression that signifies divine opposition or judgment against an individual or group. This concept is rooted in the understanding of God's sovereignty and justice, where His "hand" symbolizes His power and authority to execute judgment or bring about consequences for actions contrary to His will.

Biblical Instances:

1. Job's Suffering:
In the Book of Job, Job experiences immense suffering and attributes his afflictions to God's hand being against him. Job laments, "For the hand of God has struck me" (Job 19:21). Here, Job perceives his trials as a direct result of divine intervention, although the narrative reveals a more complex interplay involving Satan's testing and God's ultimate purposes.

2. Israel's Rebellion:
Throughout the Old Testament, the nation of Israel often faced God's hand against them due to their disobedience and idolatry. In Judges 2:15, it is recorded, "Wherever they went, the hand of the LORD was against them for harm, as He had sworn to them, and they were in great distress" . This reflects the covenantal relationship where blessings and curses were contingent upon Israel's faithfulness to God.

3. Saul's Downfall:
King Saul is another example where God's hand turned against an individual due to disobedience. After Saul's failure to fully obey God's command regarding the Amalekites, the prophet Samuel declares, "The LORD has torn the kingdom of Israel from you today and has given it to your neighbor, who is better than you" (1 Samuel 15:28). Saul's subsequent struggles and ultimate demise are seen as manifestations of God's hand against him.

4. Nations Opposing Israel:
The prophets often spoke of God's hand against nations that opposed Israel or acted wickedly. In Isaiah 14:26-27, God declares His purpose against the nations: "This is the plan devised for the whole earth, and this is the hand stretched out over all the nations. The LORD of Hosts has purposed, and who can thwart Him? His hand is stretched out, and who can turn it back?" . This illustrates God's sovereign control over history and His ability to judge nations.

Theological Implications:

The concept of God's hand against someone underscores the biblical themes of justice, holiness, and the consequences of sin. It serves as a sobering reminder of the seriousness of disobedience and the reality of divine judgment. However, it also highlights God's desire for repentance and restoration, as seen in numerous calls for Israel and individuals to return to Him and receive mercy.

Application for Believers:

For believers, understanding the notion of God's hand against someone encourages a life of obedience and reverence. It calls for self-examination and a commitment to align one's life with God's will, recognizing that while God is just, He is also merciful and gracious to those who seek Him with a contrite heart.